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GHRP-6 is a peptide in the growth factor family. It has strong effect on the release of Growth Hormone (GH). Its main use is to promote food intake by stimulating hunger and aid in energy metabolism. It can be used in the treatment of GH deficiency as well as cachexia, eating disorders and obesity. Background Although still relatively new, peptides have recently become popular as performance enhancing drugs. GHRP-6 is currently available from a few research companies. Action The major side effect accompanied by the use of GHRP-6 is a ...
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MGF (mechano growth factor) has been used by bodybuilders and athletes for a few years already. After resistance exercise, IGF-1 is released within the muscle. Specifically, at this time, immediately following the mechanical use of a muscle, the IGF-I gene is spliced towards MGF which initiates hypertrophy and repair of local muscle damage. It does so both by activating muscle stem cells and satellite cells, but also via various other anabolic processes. (1) It differs from “regular” IGF-1 mainly due to it’s C-Terminal sequence. Background It...
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What is PEG-MGF or PEGylated mechano growth factor? MGF is a splice variant of the IGF gene which increases stem cell count in the muscle and allows for muscle fibers to fuse and mature. This is a process required for growth of adult muscle. Natural MGF is made locally and does not travel into the bloodstream. Synthetic MGF is water based and when administered intramuscularly, travels into the bloodstream. MGF is only stable in the blood stream for only a few minutes. PEGylation is the act of attaching a Polyethylene glycol (PEG) structure to ...
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Melanotan I Melanotan I has not been sparking the interest of the public near as much as Melanotan II. See below as to why: Melanotan II Melanotan II has aphrodisiac properties. Palatin Technologies of New Jersey has developed another hormone targeted towards Sexual dysfunction based upon melanontan II which they call Bremelanotide (formerly called PT-141). Bremelanotide is a metabolite of melanotan II that lacks the C-terminal amide function. Bremelanotide is currently in clinical trials to treat erectile dysfunction and sexual arousal diso...
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The efficient and effective manufacture of recombinant proteins, antibodies, vaccines and viral products in animal cells requires a source of growth factors or some means of growth factor signaling to cells. The traditional method is to provide an external source of growth factors, primarily through the addition of fetal bovine serum to culture media. However, many sectors of the biotechnology and pharmaceutical industries are now demanding pure recombinant growth factors, made under the highest quality standards, or inclusion in serum-free med...
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There are primarily two theories as to how hGH (human growth hormone) exerts its growth promoting effects. The first theory is called the Dual Effector theory. The second theory is called the Somatomedin (“mediator of growth”) Hypothesis. Both theories are fairly strait forward. Let?s start with the Dual Effector theory. The Dual Effector theory states that GH itself has anabolic effects directly on body tissues. This theory has been supported by studies looking at the effects of injecting GH directly into growth plates. Genetically altered st...
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